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Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

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Acute kidney injury (AKI) is a well-established complication of severe malaria in adults [13], but only recently it has been recognized as a common complication in children with severe malaria [10]. Prior studies established an association between AKI and mortality in severe malaria [913]. The present study confirms a strong association of AKI with mortality in children, with over 60% of deaths occurring in children with AKI. This study also demonstrated an association between AKI and persistent neurologic deficits in children with CM, and long-term neurocognitive impairment in children with

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