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A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

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The development and piloting of the RRNA process demonstrates that a global partnership, through effective use of time zones, can deliver a robust summary of much of the published clinical research evidence on Lassa fever within 5 days in response to an outbreak. The results show that the RRNA methodology can be a valuable tool for rapidly identifying gaps in evidence and informing clinical research priorities in response to (re-) emerging outbreaks globally, ideally combined with an expert panel for further refinement of the research priorities.

Key strengths of the process were the use of experienced

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