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Estimated nationwide impact of implementing a preemptive pharmacogenetic panel approach to guide drug prescribing in primary care in The Netherlands

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This study provides an estimate of the potential nationwide clinical impact of a pre-emptive pharmacogenetic panel approach in primary care in The Netherlands. Based on frequencies of actionable phenotypes gathered in a pilot study of 200 patients and nationwide prescription data (n = 3,628,597), we inferred that in 23.6% of the first prescriptions of the selected 45 drugs a gene-drug pair is present [24]. If pre-emptive genetic testing of the panel consisting of eight genes had been performed in this population, we estimate that 5.4% of the new prescriptions an intervention at the start of therapy

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