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Defining responders to therapies by a statistical modeling approach applied to randomized clinical trial data

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When many drugs become available for a disease, new challenges arise for clinicians, based on the possibility to make a choice. On the other hand, the scientific breakthroughs in our understanding of how a person’s unique molecular and genetic profile makes them susceptible to respond to specific treatments for some medical conditions have made it possible to identify patient subgroups who would benefit the most from specific therapies. This is not the case for MS: since the first disease-modifying drug was approved in 1993, the approach to therapies has evolved in the direction of initiating

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