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Optimising trial designs to identify appropriate antibiotic treatment durations

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Important considerations when designing a randomised trial to identify optimal antibiotic treatment durations include (1) the ability to accurately estimate the duration–response curve, (2) the ability to minimise the risk of bias, (3) the possibility to drop poorly performing arms, and (4) statistical efficiency.

Estimating duration–response curves

A major benefit of estimating a duration–response curve is that the effects of durations not included in the trial can also be estimated provided that there is sufficient data from neighbouring durations. This applies to all four alternative

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