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Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis

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In this cross-sectional study, we explored longitudinal associations between serum IGF1 and early CVD in RA. We showed harmful consequences of normal-low levels of IGF1 for the increase in the eCVR in female RA patients < 50 years and premature development of new CVD events. The profile of new CVD events consisted of the established complications of hypertension including ischemic stroke, atrial fibrillation, and aorta aneurysm, which indicated that hypertension was an essential clinical sign of IGF1-related CVD of the studied patients. Indeed, the patients with low IGF1 demonstrated higher BP

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